Development of small molecule, drug-like TGIF inhibitors
TGIF as a drug target
TFIG (TG-Interacting factor) proteins include TGIF1, TGIF2, TGIF2LX and TGIF2LY proteins. TGIF2 proteins is identified as an oncogene in medullablastuma. TGIF is essential for mammary and lung tumorigeneis. We aim to develop drug screening tools for development of TGIF small molecule inhibitors.