PIPELINE

Developing next generation therapeutics

MEIS INHIBITORS

MEIS proteins includes MEIS1, MEIS2 and MEIS3 proteins. MEIS proteins have been shown to interact with PBX and HOXA9 proteins. MEIS proteins are known as an oncogene and overexpressed in various cancers including leukemia.

PBX INHIBITORS

PBX (Pre-B-cell leukemia transcription factor) proteins include PBX1, PBX2 and PBX3 proteins. E2a-Pbx1 HD fusion protein is an oncogene driving inappropriate expression and producing acute myeloid leukemia. ​

TGIF INHIBITORS

TFIG (TG-Interacting factor) proteins include TGIF1, TGIF2, TGIF2LX and TGIF2LY proteins. TGIF2 proteins is identified as an oncogene in medullablastuma. TGIF is essential for mammary and lung tumorigeneis.

HOXA9 INHIBITORS

HOXA9 protein is highly expressed in leukemia and shown to be the single most predictive of marker for poor prognosis. HOXA9 and MEIS1 synergize to produce aggressive leukemia
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