Development of Drug-Like Small Molecule PBX inhibitors
PBX as a drug target
PBX (Pre-B-cell leukemia transcription factor) proteins include PBX1, PBX2 and PBX3 proteins. E2a-Pbx1 HD fusion protein is an oncogene driving inappropriate expression and producing acute myeloid leukemia.
PBX related publications
Fatih Kocabas, Li Xie, Jingjing Xie, Zhuo Yu, Ralph J. DeBerardinis, Wataru Kimura, SuWannee Thet et al. "Hypoxic metabolism in human hematopoietic stem cells." Cell & Bioscience 5, no. 1 (2015): 39 [Impact Factor: 3.63] PDF (Pbx-Luc reporter paper)
Merve Aksoz, Raife Dilek Turan, Esra Albayrak, Fatih Kocabaş*. Emerging Roles of Meis1 in Cardiac Regeneration, Stem Cells, and Cancer. Current drug targets. 2017 Jul 24. doi: 10.2174/1389450118666170724165514 Full text (Association of Pbx with Meis1)
Raife Dilek Turan, Enes K. Ergin, Fatih Kocabas. The Establishment of Homeobox Family Inhibitor Library and Meis1 Reporter Assays. 3rd International BAU Drug Design Congress. Oct 1-3. 2015. Istanbul. (Analysis of Pbx and all other Hox family of proteins for possible known inhibitors)