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MEIS inhibitor-2 (MEISi-2)

Description: MEIS inhibitor-2
Synonyms: MEISi-2, small molecule inhibitor-2 of MEIS proteins, small molecule inhibitor of MEIS homeodomain, small molecule inhibitor of MEIS1, small molecule inhibitor of MEIS2, small molecule inhibitor of MEIS3, 
Chemical Formula: C18H14N2O3
Purity: ≥95% (HPLC)
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Cat. Number
Packsize
Availability
Pricing
​MEISi2-5mg
5 mg
In stock
​​Inquire
​MEISi2-10mg
10 mg
In stock
​Inquire
​MEISi2-25mg
25 mg
​In stock
​Inquire

Applications

MEIS proteins have been implicated in various cellular processes including regeneration, stem cell/progenitor function, cellular metabolism, cell proliferation, redox state, apoptosis, RLS and tumorigenesis. Small molecule MEISi inhibits transcriptional activity of MEIS proteins by targeting the homeodomain of MEIS proteins.
​
​We have used our proprietary tools and expertise in MEIS biology to develop MEIS inhibitors. We have performed in silico, in vitro, ex vivo and in vivo assays to validate small molecule MEIS inhibitors. Newly developed small molecule MEIS inhibitors are cell-permeant, and dose dependent. They could be used to target MEIS related pathways. 

​MEISi-2 or MEISi-EX may block cancer growth in vitro. MEISi-2 can downregulate expression of MEIS1 target genes including Hypoxia inducible factor (HIF)-1α and HIF-2α, and associated glycolysis genes HK2, Eno1, Glut1, and LDHA. Apoptosis can be induced with MEISi-2 treatments. 

Technical Data

Property
Description
M. Wt
306.32
Formula
C18H14N2O3
Storage
−20°C
Purity
​≥95% (HPLC)
Form
Powder
Color
Yellow
Gene Information
Meis1, Meis2 and Meis3
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. MEINOX products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

-
​Solvent
Max Conc. mg/mL
​Max Conc. mM
​Solubility
DMSO
30.63 
100
​Solubility
Water
Not determined
Not determined
​Solubility
PBS
Not determined
Not determined

Preparing Stock Solutions

The following data is based on the product molecular weight 306.32​. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions
Concentration / Solvent Volume / Mass
1 mg
​5 mg
​10 mg
1 mM
3.26 mL
16.32 mL
32.65 mL
5 mM
0.65 mL
3.26 mL
6.53 mL
​10 mM
0.33 mL
1.63 mL
3.26 mL
​20 mM
0.16 mL
0.82 mL
1.63 mL

Safety Information

Safety Information
Description
​Personal Protective Equipment 

Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
RIDADR
NONH for all modes of transport

Product Data Sheets

Certificate of Analysis / Product Datasheet
Safety Datasheet (MSDS)
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  • Home
  • Technology
    • Pipeline
    • Publications
    • Patents
    • RUO Products >
      • MEISi-1
      • MEISi-2
      • Meinox Small Molecule Library
  • News
  • About Us
    • Careers
    • Investors
    • Partners
  • Contact