MEIS inhibitor-1 (MEISi-1)
Description: MEIS inhibitor-1
Synonyms: MEISi-1, MEISi-STEM, small molecule inhibitor-1 of MEIS proteins, small molecule inhibitor of MEIS homeodomain, small molecule inhibitor of MEIS1, small molecule inhibitor of MEIS2, small molecule inhibitor of MEIS3,
Chemical Formula: C24H24N2O3
Purity: ≥95% (HPLC)
Synonyms: MEISi-1, MEISi-STEM, small molecule inhibitor-1 of MEIS proteins, small molecule inhibitor of MEIS homeodomain, small molecule inhibitor of MEIS1, small molecule inhibitor of MEIS2, small molecule inhibitor of MEIS3,
Chemical Formula: C24H24N2O3
Purity: ≥95% (HPLC)
Applications
MEIS proteins have been implicated in various cellular processes including regeneration, stem cell/progenitor function, cellular metabolism, cell proliferation, redox state, apoptosis, RLS and tumorigenesis. MEIS inhibitor-1 inhibits transcriptional activity of MEIS proteins by targeting the homeodomain of MEIS proteins.
We have used our proprietary tools and expertise in MEIS biology to develop MEIS inhibitors. We have performed in silico, in vitro, ex vivo and in vivo assays to validate small molecule MEIS inhibitors. Newly developed small molecule MEIS inhibitors are cell-permeant, and dose dependent. They could be used to target MEIS related pathways.
MEISi-1 can induce hematopoietic stem cell proliferation and self-renewal ex vivo and in vivo. MEISi-1 may downregulate expression of MEIS1 target genes including Hypoxia inducible factor (HIF)-1α and HIF-2α, and associated glycolysis genes HK2, Eno1, Glut1, and LDHA.
We have used our proprietary tools and expertise in MEIS biology to develop MEIS inhibitors. We have performed in silico, in vitro, ex vivo and in vivo assays to validate small molecule MEIS inhibitors. Newly developed small molecule MEIS inhibitors are cell-permeant, and dose dependent. They could be used to target MEIS related pathways.
MEISi-1 can induce hematopoietic stem cell proliferation and self-renewal ex vivo and in vivo. MEISi-1 may downregulate expression of MEIS1 target genes including Hypoxia inducible factor (HIF)-1α and HIF-2α, and associated glycolysis genes HK2, Eno1, Glut1, and LDHA.
Technical Data
Property |
Description |
M. Wt |
388.467 |
Formula |
C24H24N2O3 |
Storage |
−20°C |
Purity |
≥95% (HPLC) |
Form |
Powder |
Color |
White |
Gene Information |
Meis1, Meis2 and Meis3 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. MEINOX products are intended for laboratory research use only, unless stated otherwise.
Solubility Data
- |
Solvent |
Max Conc. mg/mL |
Max Conc. mM |
Solubility |
DMSO |
38.84 |
100 |
Solubility |
Water |
Not determined* |
Not determined* |
Solubility |
PBS |
Not determined* |
Not determined* |
*Soluble in %10 DSMO in water or PBS
Preparing Stock Solutions
The following data is based on the product molecular weight 388.467. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions
Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
1 mM |
2.57 mL |
12.87 mL |
25.74 mL |
5 mM |
0.51 mL |
2.57 mL |
5.15 mL |
10 mM |
0.26 mL |
1.29 mL |
2.57 mL |
20 mM |
0.13 mL |
0.64 mL |
1.29 mL |
Safety Information
Safety Information |
Description |
Personal Protective Equipment |
Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
RIDADR |
NONH for all modes of transport |
Product Data Sheets
Certificate of Analysis / Product Datasheet |
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