hCA-II inhibitor-1 (hCAIIi-1)
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Description: hCA-II inhibitor-1
Synonyms: hCA-II inhibitor-1 , hCAIIi-1, CA-II inhibitor, carbonic anhydrase inhibitor, Small molecule inhibitor-1 of human carbonic anhydrase-II enzyme Chemical Formula: C18H15FN2O3S3 SMILES: S=C3S/C(=C/c1cccc(F)c1)C(=O)N3CCc2ccc(cc2)S(N)(=O)=O Purity: ≥95% (HPLC) Compound ID: Mx00900 |
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Applications
Carbonic anhydrase (CA) enzymes are zinc‐containing metalloenzymes that maintain pH homeostasis, and they catalyze the CO2 hydration. hCAs are involved in different physiological as well as pathological processes. In humans, they are divided into 16 isoform forms varying according to tissue distribution and cellular localization (cytosol, membrane, and mitochondria). CA isoforms play a role in a number of biological processes, including acid–base balance control, tumorigenicity, ureagenesis, gluconeogenesis, bone resorption, and calcification. Thus, they are considered a well-established therapeutic target for treatment of a wide range of pathological disorders.
Proprietary tools and expertise in both biology and chemistry were used to develop novel hCA-II inhibitors. In silico, in vitro assays were used to validate small molecule hCA-II inhibitors. The enzyme inhibition activity of newly synthesized compounds on carbonic anhydrase (II) was evaluated. It was found that the IC50 values new molecules were in nanomolar level and much smaller than those of sulfanilamide (reference compound, IC50 of 3.5 μM). hCAIIi-1 was among the most potent carbonic anhydrase (II) inhibitor with the lowest IC50 value.
Proprietary tools and expertise in both biology and chemistry were used to develop novel hCA-II inhibitors. In silico, in vitro assays were used to validate small molecule hCA-II inhibitors. The enzyme inhibition activity of newly synthesized compounds on carbonic anhydrase (II) was evaluated. It was found that the IC50 values new molecules were in nanomolar level and much smaller than those of sulfanilamide (reference compound, IC50 of 3.5 μM). hCAIIi-1 was among the most potent carbonic anhydrase (II) inhibitor with the lowest IC50 value.
Technical Data
Property |
Description |
M. Wt |
422.52 |
SMILES |
S=C3S/C(=C/c1cccc(F)c1)C(=O)N3CCc2ccc(cc2)S(N)(=O)=O |
Storage |
−20°C |
Purity |
≥95% (HPLC) |
Form |
Powder |
Gene Information |
Carbonic anhydrase (CA) enzymes. Among these, CA I–III, CA VII, and CA XIII are cytosolic enzymes; CA VA and CA VB are located in the mitochondria; CA IV, CA IX, CA XII, and CA XIV are membrane‐bounding enzymes; and CA VI takes place in saliva and milk. |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. MEINOX products are intended for laboratory research use only, unless stated otherwise.
Solubility Data
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Solvent |
Max Conc. mg/mL |
Max Conc. mM |
Solubility |
DMSO |
>10 |
100 |
Solubility |
Water |
Not determined |
Not determined |
Solubility |
PBS |
Not determined |
Not determined |
Safety Information
Safety Information |
Description |
Personal Protective Equipment |
Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
RIDADR |
NONH for all modes of transport |
